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A posttest-only, quasi-experimental study was conducted to investigate the effect of two problem-based learning environments on students’ self-regulation of learning and students’ level of cognitive load. The study involved 40 graduate nursing students from two nursing courses where problem-based learning was the principal method of instruction. Twenty students from an online course and 20 students from a face-to-face course received one ill-structured problem weekly in their respective courses over the 4-week duration of this study.