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The potential of virtual patient simulations (VPS) for enhancing medical education is well documented. However, VPS have not been widely integrated into medical school curriculum and many questions still remain. This session demonstrates key features of a cranial nerve VPS, summarizes the design and results of 5 initial studies, and illustrate how the application of instructional design (ID) practices, experiential learning principles, and tactics for gamifying instruction advanced the design of a VPS.