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Much of science learning in school today is often disconnected from the curiosity and excitement of scientific discovery and engineering (Marino et al., 2013). Game-based learning has the potential to provide simulated real world environments where students can engage in three-dimensional learning of disciplinary core ideas, scientific processes, and crosscutting patterns as called for in the Next Generation of Science Standards. This paper discusses a theory-based design model for game-based science inquiry and learning.