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This study proposes and tests a theoretical model of STEM participation that examines factors shaping the decision to pursue STEM fields of study among four-year institution entrants using a nationally representative sample of high school graduates from 2004. Integrating prior literature and the social cognitive career theory, this study draws upon data from the first and second follow-up interviews of the Education Longitudinal Study (ELS: 04/06) to examine how choice of STEM fields is related to a variety of high school and postsecondary factors. Results from this study have implications for improving K-12 and postsecondary practices and activities that promote participation in STEM, particularly those that target underrepresented student populations.