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This study investigates students’ perceptions and achievement in case-based and lecture-based settings, hereby making use of student profiles based on motivation and approach to learning. A quasi-experimental design was set up consisting of four learning environments that differed in the degree to which case-based and lecture-based learning was implemented (either separately or combined). Participants were 1098 first-year student teachers who took a course on child development. Results showed that perceptions of autonomously motivated deep-strategic learners (profile 1) were significantly more positive in the four learning environments than perceptions of little motivated and less pronounced deep-strategic learners (profile 2). With regard to achievement, both student profiles did not differ significantly.