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As western society becomes increasingly reliant on scientific information to make decisions, citizens must be equipped to understand how scientific arguments are constructed. In order to do this pre-service teachers must be prepared to teach scientific argumentation in the classroom. This study investigated how instruction in the Toulmin Argumentation Protocol (TAP) impacted pre-service science teachers' ability to write sound and logical scientific arguments. The study occurred in the context of a pre-service methods class on the socio-scientific realm of secondary science education at a university in the USA. Through the use of a sequential mixed-methods investigation findings indicate that there was a positive impact on pre-service science teachers ability to construct sound scientific arguments through instruction in the TAP.