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This longitudinal transition study was conducted in collaboration with teachers who interviewed with students with disabilities who graduated from 177 school districts in a Midwestern state. Special education students were interviewed at exit and one year following graduation using a survey based on the National Longitudinal Transition Study. The authors developed and tested three regression models—two to predict full-time employment and one to predict college enrollment after graduation. After controlling for gender, minority status, and level of disability, the authors found that students who graduated from career-technical education and work study programs were more likely to enter full-time employment after graduation, but this relationship was mediated by gender, minority status, and disability.