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Due to the highly interdisciplinary and applied nature of Biomedical/BioEngineering, the education of future biomedical engineers (BME) requires new approaches. Oftentimes BME graduates are asked to be problem-solvers (i.e. doers) and yet students are required to master biological principles through traditional didactic approaches (i.e. lectures). We redesigned the traditional lecture-based cell and molecular biology class within the X Y Z University (Xx Univ) BME curriculum with the goal of preparing students for the real-life expectations of the BME professional community. This paper presents the lessons we learned while engineering a pedagogical shift from lecture- based instruction to a Problem-based Learning approach. Our discoveries were then used to inform redesign of the next iteration of the course.