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In 2009 the White House Office of Science and Technology Policy issued a Request for Information (RFI) asking for input into the issues of university commercialization, the valley-of-death, innovation and entrepreneurship, and proof of concept centers. Two hundred and five individuals and organizations representing consortia, foundations, non-profits, proof of concept centers, private companies, and universities responded to the RFI in 2010. This study is an analysis of those responses. A 5-stage, iterative process was employed for summarizing comments into a manageable set of common themes. The final analysis resulted in twelve categories that were used to portray the data: Challenges, Collaboration, Communication, Ecosystem, Education, Entrepreneurship, Funding, Leadership, Multidisciplinarity, Proof of Concept, Risk, and Strategy. Recommendations are provided.