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This study explored how scientific humor is integrated into exam problems developed by a college instructor to assess learning in a genetics course. Through a qualitative exploration with a dual analytical focus on humorous views and practices, we examined the professor’s humor-based science pedagogy. It was found that the professor viewed humor as a pedagogical strategy that integrated scientific and social meanings. Translation of these views into practice led to the development of humorous science problems with increasing cognitive complexity: identification, classification, and analogy. The significance of this study is that it underscores the content-embedded nature of scientific humor.