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We used a mixed methods research design with an instructional intervention of guided inquiry and formative assessment that included explicit instruction to improve higher order thinking of students in grade 6 science. In the first study the researchers taught the intervention to 37 students. In the second study one teacher from the first year taught her class (n=15), and we taught the intervention in an additional school (n=20). For both studies there was a comparison group. Data comprises pre-posttest scores of critical and higher order thinking, student responses to formative assessment tasks, and audio recordings/transcripts of pre-post instructional student focus groups. The results show, quantitatively and qualitatively, that higher order thinking improved for students in the intervention groups.