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The present study combined the insight of prospect theory and achievement motivation theory, and was aimed at demonstrating that the neural basis of the asymmetric relation between avoidance and approach achievement motivation.The fMRI results indicated that activation in right dorsolateral prefrontal cortex is greater than in left dorsolateral prefrontal cortex inconsistent condition and similar pattern revealed in consistent condition. Moreover, the activation difference existed between right and left dorsolateral prefrontal cortex which the former activated significantly greater than the latter.