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This study aimed to investigate the effectiveness of two different teaching methods on learners’ self-regulation. OpenCourseWare was integrated into the flipped classroom model (experimental group) and distance learning (control group). Overall, 181 freshmen taking a course on physics were allowed to choose their own class based on their preferred teaching method (experimental or control group). The findings indicated that when comparing the means for the six categories of self-regulation, the results showed that learners from the experimental group had significantly higher scores for the category of help-seeking. The results of this study can serve as a reference for future studies on the flipped classroom model and OpenCourseWare, as well as for teachers and researchers in related fields.