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This research is a mixed-methods, 3-year study investigating the effects of science and mathematics teacher professional development (PD) on teachers in 2 middle schools in neighboring rural, low-income districts in a southeastern U.S. state. The 21 teachers experienced 2-3 years of inquiry-based, technology-infused PD. We collected state end-of-grade (EOG) mathematics and science assessment data for a total of 2300 students. We found that there were significant increases in both the teachers’ reform-based teaching beliefs and comfort using new technologies, demonstrating a transformative shift. Students who had more project teachers earned significantly higher EOG assessments; this effect was significant for African American but not Caucasian students, with the most impressive gains for students with project teachers for all 3 years.