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The current study examined how demographics and family factors influenced Asian immigrant adolescents’ psychological wellbeing. With data drawn from the second wave of Children of Immigrants Longitudinal Study (CILS), we examined Asian immigrant students’ (N=2,201, 49.2% males, 50.8% female) self-esteem and depression and their predictors. Analysis of variances and hierarchical regression were conducted, the results indicated that female students reported lower level of self-esteem and higher level of depression than males. Family cohesion and parent-child conflict were related to students’ self-esteem and depression. Mother’s education and students’ English proficiency were related to Asian students’ self-esteem, but not depression. Significance of the study was discussed.