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Onwuegbuzie, Leech, and Collins (2012) demonstrated how the following five qualitative data analysis approaches can be used to analyze and to synthesize information extracted from a literature review: constant comparison analysis, domain analysis, taxonomic analysis, componential analysis, and theme analysis. In a similar vein, Onwuegbuzie and Frels (2014) outlined how discourse analysis can be used. Thus, the purpose of this article is to provide a framework for using another qualitative data analysis technique to analyze and to interpret literature review sources—a process that we call a Qualitative Comparative Analysis-Based Research Synthesis (QCARS). Using a real review of the literature and with the aid of screenshots, we illustrate how to conduct a QCARS using a qualitative comparative analysis software program.