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The impact of case-based learning (CBL) and reflection activities on Doctor of Physical Therapy (DPT) students’ clinical reasoning using the Self-Assessment of Clinical Reflection and Reasoning (SACRR; Royeen, Mu, Barrett, & Luebben, 2001) was examined. Data (N = 27) were collected from 2nd-year DPT students at three time points across one semester. The results indicated that there were no statistically significant differences between time points 1 and 2 (p > .05) before the intervention; however, from time points 2 to 3, there was a statistically significant increase in SACRR scores (p = .001). Evidence from this study shows that the combination of reflection with CBL activities can lead to increases in clinical reasoning, which can lead to improved patient outcomes.