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Social Network Analysis (SNA), a methodological approach that enables the mathematical examination of inter-professional relationships, can be an important tool for understanding and leveraging the social relationships that support and restrain instructional innovation and the quality and pace of school reform initiatives. In this paper a case study is presented in which school leaders employed SNA to examine formal and advice-seeking networks among teachers, staff, and administrators, and used the findings to reduce teacher isolationism, promote efficient communication, and increase system capacity for instructional innovation. Challenges and opportunities associated with the use of SNA to investigate and enhance quality of teaching and learning is also discussed.