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The purpose of this study is to expand the empirical literature on the relationship between R&D and economic growth by examining the effects of federal R&D expenditures on the U.S. national economy. This study sought to answer the following research question: Is investment in academic R&D a strong predictor of national economic growth when controlling for such factors as capital, labor, and population? We were guided by endogenous growth theory, draw on data from over a 60-year period (from 1953 to 2012, and use cointegration analysis.