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The purpose of this study was to enhance students' mastery of course material in a second semester calculus course and assess the effectiveness of a traditional “lecture-based” instructional model compared to a modified “flipped classroom” model using a mixed method research design. Evaluation of effectiveness was measured by having students in all four courses take the same pre-post exams and participate in a survey to assess their opinion of each instructional model. Participants in the flipped course had similar content knowledge gains as the lecture-based course. Based on responses obtained in blinded student surveys, we found that the use of an online homework system and in-class quizzes were critical motivating factors that likely contributed to the increase in student performance.