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Systems thinking skills required to understand complex systems have been emphasized in education as a core aspect of science literacy, and more recently, as a critical 21st century skill. Although several studies have investigated how games can be used to facilitate students’ systems thinking skills, little is known about how teachers can design game-based curricula. In this study, we investigate the efficacy of a pedagogical framework called Game-Based Structural Debriefing (GBSD) as a means to bridge the affordances of games with curriculum activities. To iteratively refine the framework in collaboration with teachers, we use design-based research to support development of a GBSD curriculum unit in the life sciences domain.