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This study examines the effect of an on-line problem based learning system on high school students in a health science program. The learning system focuses on critical thinking skills as they relate to determining the diagnosis of a disease based on physical assessment and the understanding of pathophysiology. The study findings suggest that the on-line review system significantly improved the student’s ability to determine the correct diagnosis from information presented in a scenario based problem format. The study was implemented after a full and comprehensive review and approval by the Human Subjects Committee at Florida State University.