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This study examines the impact of an online teacher professional development, focused on academic literacy in high school science classes. A one-year randomized control trial measured the impact of Internet-Based Reading Apprenticeship Improving Science Education (iRAISE) on instructional practices and student literacy achievement in 27 schools in Michigan and Pennsylvania. Researchers found a differential impact of iRAISE favoring students with lower incoming achievement (although there was no overall impact of iRAISE on student achievement). Additionally, there were positive impacts on several instructional practices. These findings are consistent with the specific goals of iRAISE: to provide high-quality, accessible online training that improves science teaching. Authors compare these results to previous evaluations of the same intervention delivered through a face-to-face format.