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To examine factors for differential employment expectations of employed adults with multiple sclerosis, this study consisted of 590 individuals who had three types of employment expectations for the next 2 to 5 years: continue employment, decrease work responsibilities, and exit employment. Findings confirmed the utility of social cognitive theory regarding the relationship between background, physiological and affective states, performance accomplishments, and proximal contextual influences and employment expectancies. Compared to those who expected to remain fully employed, those who planned to decrease work responsibilities or exit the workforce were older, more severely disabled from the disease, and, in the case of those planning to decrease their job duties, less likely to have access to suitable housing.