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This research investigates the relationship between achievement goals, self-regulated learning and clinical reasoning performance in a computer-based learning environment, BioWorld. Achievement goal questionnaires were analyzed along with computer trace data that revealed self-regulated learning behaviors. A path model was constructed using maximum likelihood method. SRL behaviors pertaining to clinical reasoning (reasoning about a diagnosis) included ordering lab tests and evidence-checking. These SRL behaviors associated with higher confidence levels, whereas evidence-linking and library searches were associated with less confidence in the final diagnosis. Certain achievement goals were negatively related to clinical reasoning and self-regulated learning. Higher performance avoidance goals predicted more evidence-linking which was related to less confidence. Performance approach goals negatively predict the efficacy of learners.