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This study examines middle school science achievement as well as motivational attributes as related to science to answer the following question: What motivational and academic performance factors predict middle school students’ achievement in science? Participants were 111 students in grades 6 through 8 from a diverse public middle school. Mathematics, English, and social studies achievement significantly predicted science achievement in addition to self-efficacy and grade motivation constructs from the Science Motivational Questionnaire-II with a large effect size. This study supports previous research that demonstrated that self-efficacy is a better predictor of science achievement than ethnicity and gender in middle school students and that students’ science achievement may be a function of mathematics and literacy skills.