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This study applied growth mixture modeling to uncover latent developmental patterns of students’ attitudes toward science through their middle and high school years. Data were drawn from Cohort Two of the Longitudinal Study of American Youth (LSAY). Analyses identified three distinct subgroups of change patterns for each of attitudes toward science utility and science self-concept. Differential group memberships were subsequently assessed for association with STEM achievement and postsecondary outcomes. The extent to which initial student, parent, and teacher college and career expectations impacted memberships in these subgroups were also examined.