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This study used evidence-based learning analytics to examine the relationship between student-student interaction and questions designed with the Practical Inquiry Model (PIM) in asynchronous online case-based discussions. Degree centrality was used to indicate students’ online communicative interaction. The findings revealed that the number of replies each student sent to others was higher for the PIM questions compared to non-PIM questions. Additionally, there was a strong positive correlation between responding to others and receiving responses for the PIM questions. Researchers and practitioners who are interested in case-based discussions and how to design discussion questions to enhance students’ online interaction will benefit from this session.