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Resilience positively influences a variety of life aspects such as academic achievement and mental health. This study explored pathways connecting life experience-learning to resilience, through self-efficacy and self-compassion. Participants were 184 American and 230 Taiwanese high school students. Structural Equation Modeling and moderated mediation analysis were applied to analyze data. The pathways were found to be effective in both samples even under the influence of attachment anxiety, stress, and anxiety. The pathways contributed to 56% and 59% of resilience in the American and Taiwanese samples, respectively. A cross-cultural comparison showed that (1) attachment anxiety less impacted the pathways in Taiwanese students and (2) Taiwanese students were more likely than their American peers to learn resilience through self-compassion.