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This mixed-methods study aimed to explore self-determination perceptions of students with learning and attention challenges in an alternative learning center at a research one university to improve the quality of departmental programing with better preventions and interventions. Most of students viewed themselves almost always to always had been provided opportunities but sometimes perform self-determined behaviors. They had high level of Thinking but medium level of Doing and Adjusting. Female students’ self-determination were significantly higher than male students. No significant differences across ethnicity categories were found. Three main themes were identified: Academic Goals, Health Goals, and Employment and Finance Goals. Awareness of different groups, myth busting, and supports were discussed to provide strategies for college students with learning and attention challenges.