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Disability simulation activities are thought to improve attitudes toward individuals with disabilities, despite some evidence to the contrary. In the absence of empirical guidance, such activities are commonly used in teacher preparation courses. The purpose of this research was to assess effects of using low-vision googles to simulate VI in an introductory special education course. Results of a cluster-randomized trial showed pre-service teachers who completed the simulation reported higher levels of interest and engagement than those in the lecture-only control condition; however, there were no significant differences in attitudes toward persons with VI, self-efficacy for working with students with VI, mastery of course content knowledge, or perceptions of learning activity usefulness. Results did not vary by gender or major.