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Students with emotional and behavioral disorders (EBD) are considered to have particularly significant support needs. Problem behaviors for students with EBD tend to continue despite intervention, remaining stable over time. Social-emotional learning (SEL) interventions represent a potential avenue for meaningful student gains. While existing reviews have examined the effects of SEL interventions across diverse student population, none have examined studies of SEL interventions targeting students with EBD. This systematic review searched electronic databases through November 2017, locating seven controlled trials evaluating SEL interventions for students with EBD. Although not consistently significant, positive results were found across all outcomes. Findings highlight the potential of SEL interventions for students with EBD and the need for additional efficacy research.