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Developing research self-efficacy is an important part of doctoral preparation. Despite the documented importance of research self-efficacy, little is known about doctoral students’ research self-efficacy in general and for students from underrepresented groups. This study examined the stability of research self-efficacy over four years, focusing on doctoral students in biological sciences (N = 332). An autoregressive path analysis was evaluated to determine the predictive power of research self-efficacy across eleven academic terms. The analysis was evaluated across gender, underrepresented minority (URM) status, and first-generation status. Results show a decrease in predictive power between the spring and summer terms of students' second year. The decrease is greater for URM and first-generation students. Additional results, future directions, and practical implications are discussed.