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This study aims to compare the performance of the Bayesian and restricted maximum likelihood (REML) estimation method in the analysis of multilevel models with small numbers of clusters and non-normal data. Simulated data were used to examine the effects of cluster size, non-normality of data, prior distributions on the parameter estimates of a two-level multilevel model. Preliminary results showed that the severe non-normality led to biased estimates of Level-2 regression coefficients for both approaches, but the Bayesian estimation method generated less biased estimates of fixed effects than the REML method. The standard error estimates of Level-2 predictor coefficients were unbiased for both Bayesian and REML. Lastly, the Bayesian approach yielded larger level-2 residual variance estimates than REML.