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Evidence indicates that mental health conditions pose a significant challenge for college students on the autism spectrum. A systematic review of the literature was conducted to identify the impact of mental health conditions on college success and to identify support services that may help students on the autism spectrum successfully complete their post-secondary education. Overall, 23 studies met inclusion criteria, spanning across the USA, Canada, UK, Australia, Belgium, China, and Japan. Data is reported according to three categories: the frequency and/or type of mental health condition experienced by students on the autism spectrum; the impact of mental health conditions on students; and the effectiveness of identified support services.