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Substantial evidence suggests that structured informal science education programs for high school students have the capacity to impact participants’ STEM interests and career trajectories. However, more work is needed to foster equitable experiences in these programs. This study includes a critical analysis and interpretation of existing literature and results from a recent study. Analyses reveal that impact to STEM career trajectories is evident across examined programs, however a significant majority of programs studied target academically high-achieving students with already well-developed STEM interests and affinities. Informal science education programs do have the potential to impact STEM trajectories for high school students of varying academic abilities, but that goal is not being reached in application-based programs due to exclusive structural policies.