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To address the challenge of STEM teacher retention, this study builds upon the revised job demands- resources theory to construct a model for examining resources, demands, and self-efficacy’s contributions to STEM teachers’ leaving intention. The findings show that a) resource is a strongest predictor for leaving intention; b) self-efficacy had significant negative effects on leaving intention; c) the mediator of stress had a strong negative effect on satisfaction and a strong positive effect on leaving intention; d) the mediator of satisfaction had a strong negative effect on leaving intention. The findings can provide references for school administrators and policymakers to develop and implement educational strategies and to increase STEM teacher retention rate.