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This study investigates whether personality traits predict high-impact practice (HIP) participation in college students. Data is drawn from 10,253 student responses at 34 institutions using the National Survey of Student Engagement (NSSE). A series of binary logistic regressions models suggest several significant personality trait predictors of HIPs, even after controlling for demographic and institutional characteristics. Specifically, students higher in extraversion, agreeableness, and intellect/openness are more likely to participate in several different HIPs, including learning communities, research with faculty, internships, and leadership. Students higher in neuroticism are less likely to participate in internships and capstone experiences. Understanding the effect personality has on HIP participation can help institutions develop programming that is appealing and inclusive for all students; regardless of personality traits.