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Nearly half of all students nationally are placed into at least one remedial course in college. Many of these students fail to complete remedial course sequences and persist to degree completion. First-Year Seminars (FYS) are one of several high-impact practices associated with increased persistence, retention, and graduation rates of college students. Inverse probability of treatment weighting (IPTW) was used to explore the effect of FYS enrollment on the academic achievement of students placed into remedial mathematics. Results from this study indicated FYS participants were more likely to earn a passing grade in their remedial mathematics course and have higher overall GPA. These results may inform strategies for supporting academically underprepared college students.