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The world's top four research university alliances were selected as research objects, and comparative analysis method was used to compare and analyze the first-class disciplines, scientific research productivity, scientific research influence and cooperation, and discipline group structure of the university alliances. The overall profile and main characteristics of the disciplines of the university alliances would reveal the gaps and characteristics of the disciplines of the international top university alliances.The study found that maintaining close links between scientific research and international frontiers, optimizing the structure of disciplines, and creating more peaks in discipline clusters have important enlightenment values for the development of university alliances.