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In response to the COVID-19 pandemic, post-secondary institutions have made swift changes, one of which being the widespread transition to online learning. This transition can impact students of various backgrounds – including those from minoritized backgrounds. Indirect effects of these impacts include psychological and economic challenges to students, thus exacerbating systemic inequalities in our society. This study investigates the in-person to online instruction change and its association with student sociocultural factors during the Spring semester 2020 in a large Midwest university. The mixed-method study surveyed 592 students and interviewed 7 faculty and 4 teaching assistants from randomly selected courses across disciplines. Findings indicated differential levels of motivation, resilience, coping mechanisms, life satisfaction, self-esteem and college belonging across race, gender and disciplines.