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This case study examines the design and use of blended learning resources with students diagnosed with moderate cognitive disabilities. The collection of K-2 blended resources examined in the study, Hero Elementary, is designed with accessibility features to support learning in the Next Generation Science Standards (NGSS), and includes television episodes, digital and analog games, non-fiction eBooks, hands-on activities, a digital science notebook, and educator resources. Findings suggest that the resources were successfully used to engage students with moderate cognitive disabilities. The findings suggest that teachers’ adaptations to the resources, including accommodations and modifications, provided students greater access to learning content. In addition, the design features of the resources supported opportunities for students to more deeply engage in the science content.