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Large sample size requirements are a limitation of multilevel structural equation modeling (MSEM) for mediation analysis with nested data structures. Recently, there has been growing interest in Bayesian methods for mediation analysis with small sample sizes; however, to date, no study has evaluated the impact of diffuse priors in Bayesian multilevel mediation analysis with latent variables when all observed variables are measured at the within-group level. This simulation study compares Bayesian and frequentist approaches in a 1-1-1 mediation model under various design conditions. Results suggest that Bayesian methods with diffuse priors do not provide a clear fix for small sample problems.