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Despite efforts to increase the number of adolescents pursuing science careers, science motivation declines during the secondary school years. To better understand individual differences in science motivation, a short-term longitudinal study (1,613 high school students) examined if a growth mindset in science ability was associated with achievement and career aspirations indirectly through motivational beliefs (i.e., expectancy beliefs, task values, and cost). Findings suggested that expectancy beliefs mediated the pathway from a growth mindset to higher grades in science, while values mediated the pathway from a growth mindset to higher STEM career aspirations. Both a growth mindset and high motivation in science are important pathways to achieving success in science.