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The COVID-19 disruption required a rapid transition to emergency, remote instruction for universities across the country (Hodges, et al., 2020). We administered a weekly check-in survey for 226 students enrolled in a gateway life sciences course beginning the week after the transition to remote instruction to monitor students’ self-regulated learning, motivation, depletion, and affect. Students who were able to maintain high levels of self-efficacy and make necessary sacrifices to support their learning were able to perform well in the course. A lack of regulation and decreased academic success was related to affective feelings of anger, familial demands, and increased activity during the transition.