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In this study, we explored middle school students’ and teachers’ meaning-making processes through a role-playing game combined with a computational modeling activity that simulated epidemic disease transmission. Student and teacher interviews were used as the primary data sources and analyzed using the Representational Constructions Affordances (RCA) framework (Prain & Tytler, 2012). Analysis of student and teacher interviews revealed how the different representations of disease transmission functioned in complementary and constraining roles for students’ meaning-making. Additionally, the teachers predominately focused on the role-playing game as a semiotic tool for meaning-making about the computational model. This has implications for both science educators and researchers aiming to support and develop teachers’ pedagogical content knowledge for incorporating computational modeling into science classrooms.