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Based on the two-wave, China Education Panel Survey data obtained from 701 Chinese junior middle school teachers, this study examined the association between job demand and job burnout, and also tested the potential mediating role of job satisfaction and the potential moderating role of teachers’ role. Results indicated that job load, but not job stress at Wave 1 was positively associated with job burnout at Wave 2 indirectly through its negative association with job satisfaction at Wave 2 among subject teachers; in contrast, for homeroom teachers job satisfaction at Wave 2 was the only factor that was identified to be negatively associated with job burnout at Wave 2.