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High school course taking has been a significant topic in education reform policy because it has the potential to increase equity in academic achievement, college enrollment, and future success for students. The purpose of this study is to provide a current and comprehensive description of the relationship between math, science, and English language course-taking and postsecondary outcomes using resent data from a nationally representative study, the high school longitudinal study (HSLS:09). The results show that course taking is related to students’ postsecondary outcomes including college enrollments, selectivity of enrolled colleges, majoring in STEM, and persistence. Results from the decision tree and the latent class analysis highlight the importance of precalculus and AP/IB courses in predicting postsecondary enrollment.