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With medical knowledge expanding exponentially and clinical practice evolving, future doctors must be lifelong learners who are willing and prepared to adjust to new circumstances. Medical educators must cultivate an intellectually curious physician leader mindset that seeks to be innovative in their problem solving and collaborative in their leadership. Results from the first two cohorts of students at a new medical school reveal that an integrated leadership curriculum along with a nine-month immersive “Innovation, Leadership and Discovery” (ILD) course supports student leadership competency development preparing them to be agents of change.