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This research investigated whether structuring a professional learning network (PLN) to include school-based co-teaching partners would amplify educators’ success in taking up and adapting evidence-based practices as meaningful in their contexts. Our research questions were: (1) What conditions did educators identify in the PLN overall that supported their co-construction of knowledge and practice development together? and (2) How did including co-teaching partners in the PLN help participants to mobilize knowledge and/or practices in the contexts they were working?